Hi DW,
I've updated my VS Professional from 2013 -> 2015, at first everything was fine.
I then wanted to use the new string interpolation in C# 6 as this was a cleaner solution then string.Format(). Because of this I had to set the target framework to 4.6, this posed a problem with all my DW installations throwing me the screen attached.
Full error message: http://pastebin.com/pVcRx5U9
Other projects (non DW and IIS express) seems to work as expected.
Trying to go back to .NET 4.5.1 does not fix the problem. Any ideas?